Retrospective birth dating of cells in humans
Ultimately, our findings also underline that the extracellular matrix and the biomechanical properties of CAs and cerebral arteries are fundamentally different. This is consistent with serial imaging data, showing that some unruptured CAs do undergo growth, including selected smaller aneurysms and a substantial proportion of larger aneurysms especially in patients who smoke.The generation of cells and its regeneration (cell turn over) in human body has been a major area of research.Several studies have been conducted using molecular markers of proliferation to calculate the age of the cell and its regeneration. Furthermore, the measurement precision in radiocarbon birth dating corresponds to a chronological uncertainty of 1 to 3 years, and current technology does not allow for better temporal resolution in samples.
These cells are not exchanged as the nonneuronal cells in the brain.
Michael’s Hospital, Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. In addition, the existing knowledge on collagen turnover in arteries is mainly derived from animal models or extracranial vessels.
M.); and Department of Surgery, University of Toronto, Toronto, Ontario, Canada (R. Aside from our preliminary birth dating study in a small patient cohort, data to support or challenge this concept are mainly derived from animal studies or mathematical models and observational studies of human CAs.
Retrospective birth dating is a generally applicable strategy to measure cell turn over in man under physiological and pathological conditions.
Analysis of cell turnover in different pathologies may further the understanding of certain diseases.